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Sensitive skin represents both a clinical condition and a subjective experience that affects an increasingly large proportion of the population. Whether stemming from innate biological factors, acquired barrier dysfunction, or heightened perception of normal sensations, reactivity complicates skincare decisions and limits access to many effective treatments. Understanding the mechanisms underlying sensitivity provides pathways to both reducing reactivity and carefully expanding tolerance to beneficial ingredients that might initially provoke responses. Defining Sensitivity: Clinical and Subjective Dimensions True sensitive skin involves measurable physiological characteristics: increased trans-epidermal water loss indicating barrier compromise, elevated levels of inflammatory mediators, higher nerve density, or reduced tolerance…